Associations of IL6 rs1800795, BLK rs13277113, TIMP3 rs9621532, IL1RL1 rs1041973 and IL1RAP rs4624606 single gene polymorphisms with laryngeal squamous cell carcinoma.

Abstract

Survival rate of laryngeal squamous cell carcinoma (LSCC) patients is not improving. To understand more complete biology of LSCC, studies focused on identification of new specific and prognostic markers are performed. The aim of current study was to evaluate the impact of five different single nucleotide polymorphisms (SNP) (IL6 rs1800795, BLK rs13277113, TIMP3 rs9621532, IL1RL1 rs1041973 and IL1RAP rs4624606) on LSCC development. A total of 891 subjects (353 histologically verified LSCC patients and 538 healthy controls) were involved in this study. The genotyping was carried out using the real-time-PCR. Statistical analysis revealed statistically significant associations between TIMP3 rs96215332 variants and LSCC in the codominant (OR=0.600; 95% CI: 0.390-0.922; p=0.020), overdominant (OR=0.599; 95% CI: 0.390-0.922; p=0.020) and additive (OR=0.675; 95% CI: 0.459-0.991; p=0.045) models. Also, significant variants of IL1RAP rs4624606 were determined in the codominant (OR=1.372; 95% CI: 1.031-1.827; p=0.030), overdominant (OR=1.353; 95% CI: 1.018-1.798; p=0.037) and additive (OR=1.337; 95% CI: 1.038-1.724; p=0.025) models. Results of the current study indicate significant associations between TIMP3 rs9621532 and IL1RAP rs4624606 gene polymorphisms and LSCC development.