Abstract
Capparis spinosa L. (caper), is a traditionally used medicinal plant and widely studied for its biological properties. We aimed for the first time to compare the biological and phenolic fingerprints of C. spinosa buds, collected from Morocco, Turkey, and Italy. Phenolic compounds, fatty acids, and essential oils were profiled by chromatographic techniques. Enzymes inhibitory activities of different extracts were tested by spectrophotometric methods. Antioxidant capacity was evaluated by different assays including free radical scavenging, reducing power, metal chelating and phosphomolybdenum. Moroccan sample showed the highest phenolic content across all extraction types followed by Italian and Turkish. Rutin was detected as main compounds in the extracts and the Italian decoction extract had highest rutin content. Moroccan samples exhibited the highest activity in microwave and Soxhlet extracts. The highest acetylcholinesterase inhibitory activity was observed in Turkish Soxhlet and Moroccan samples. The best butyrylcholinesterase inhibitory effects were also detected in the Italian extracts. The predominant fatty acid was α-linoleic acid (C 18:3 ω3; 28.65%), observed from Turkish sample. n-Hexadecanoic acid was the main component in the essential oils (13.9%, 25.03%, and 36.67% for Italian, Turkish, and Moroccan samples, respectively). Our results strongly advocate that future formulation of C. spinosa as active ingredient should also take into account the geographical origins and extraction techniques.
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