Impact of different doses of Malathion on the selected blood parameter in albino rats (Rattus norvegicus)

Abstract

Malathion is an organophosphate pesticides commonly used to eradicate the pest of agricultural crops. It is routinely used to protect the ornamental and home gardening plants. Malathion is found in market by its trade name called cythion. In Indian scenario farmers and spray men use pesticide in their fields ignoring its toxicological effects. The main target organs of any toxicant in human body are liver and kidney.Present study is based on the effects of different dose of Malathion on blood biochemical parameter like blood sugar, blood urea, creatinine and bilirubin. These four parameters are used to observe the behavior of liver and kidney in albino rats. Four doses of Malathion has been selected as 25 mg, 50mg, 75mg and 100mg per kilogram body weight per day for 7 days and 15 days of treatment. Findings indicate that at normal condition the value of sugar was 121.54 +14.44 mg/dl , blood urea 41.27 + 3.13 mg/dl , blood bilirubin 0.76 + 0.10 mg/dl and value of creatinine was observed as 0.85 + 00.52 mg/dl. with different doses of Malathion after 7 and 15 days the value of blood sugar significantly decreases upto 78.52 + 10.25 mg/dl at higher dose while blood urea value significantly increased up to 50.88+4.8 mg/dl, the value of creatinine significantly increased 1.05 + 0.18 mg/dl and bilirubin also increased significantly 2.20 +0.64mg/ dl. The fluctuation in parameter represents the abnormal behavior of liver and kidney of albino rats due to the toxicity of pesticide.