Abstract
We investigated the correlation between type 2 diabetes (T2D)-related genes and the clinical characteristics of T2D in the Chinese Han population. Our study included 319 patients and 387 controls. Age, gender, clinical features, medications intake and biochemical blood profiles were analyzed. Genotyping was performed on a total of 18 single nucleotide polymorphisms previously reported to be associated with T2D. Our analyses revealed that the CT genotype of ARHGAP22 rs4838605 is associated with T2D risk. Upon analyzing the subjects’ clinical characteristics, we found that for rs2811893, the TT genotype correlated with high creatinine levels, while the AA genotype of rs17045754 and the TT genotype of rs4838605 correlated with elevated triglyceride levels. In addition, the AA genotype of rs17376456 and the TT genotype of rs6214 (p = 0.006) correlated with elevated hemoglobin A1c levels. Lastly, those carrying the TT genotype of rs7772697 and the CA genotype of rs3918227 exhibited higher mean body mass index and Cystatin C than controls. Our results showing that the ARHGAP22 gene is associated with an increased risk of T2D, and that seven SNPs in MYSM1, PLXDC2, ARHGAP22 and HS6ST3 promote T2D progression and could help predict the clinical course of T2D in patients at risk.
Highlights
Hallmarks of type 2 diabetes (T2D) include insulin resistance and reduced insulin secretion [1,2,3,4]
Our analyses revealed that the CT genotype of ARHGAP22 rs4838605 is associated with T2D risk
We found that the minor allele “C” of rs4838605 has an association with increased T2D risk under the overdominant model (OR = 1.57; 95% confidence intervals (95% CIs) = 1.08–2.27; p = 0.018) (Table 5)
Summary
Hallmarks of type 2 diabetes (T2D) include insulin resistance and reduced insulin secretion [1,2,3,4]. Hundreds of studies reported associations between single nucleotide polymorphisms (SNPs) and T2D risk (http://diabetes.diabetesjournals.org). In the past few years, many additional T2D risk loci have been identified including TCF7L2, FTO, HHEX, SLC30A8, HMG20A, IGF2BP2, MYSM1, TNFSF4, MYT1L, KIAA0825, VEGFA, PLXDC2, CREB5, NOS3, ARHGAP22, IGF1 [13,14,15,16,17,18,19,20,21]. For many of the reports the association between SNPs and T2D risk might have been false-positives or of minor impact in different populations. Single population studies might not fully explain associations between SNPs of candidate genes and T2D risk
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