Impact of diabetes mellitus on central corneal thickness and anterior chamber depth

Abstract

Background- Diabetic keratopathy is a known entity that affects approximately 70% of diabetic population and includes decrease in corneal endothelial cell density (CED) and hexagonality, polymegathism, pleomorphism, increase in CCT, higher corneal autofluorescence, and lower corneal sensitivity. Objectives: To study the central corneal thickness (CCT), anterior chamber depth (ACD) in patients with type II diabetes mellitus and compare it with healthy controls. Methods: This was a prospective; hospital‑based study approved by institutional ethical committee conducted on 50 type II diabetics and 50 healthy controls. Complete ophthalmic examination was performed. CCT was measured using an ultrasound pachymeter, ACD, and AL was measured using an optical biometer. Analysis of data was done by using SPSS software ver. 22. Data were statistically described in terms of mean (±SD), frequencies (number of cases) and percentages when appropriate. Results: The mean age of all recruited patients was 57.52 ± 9.66 years. The study was female preponderance (60%). Mean IOP in diabetic was 13.11 while in Non-diabetics was 13.4 and it was not significant. The mean CCT in diabetics 511 (±33.42) μm was significantly thicker than the CCT of healthy controls 505.70 (±32.19) μm (P < 0.01).