Abstract
BackgroundSchizophrenia is a complex mental disease whose cause is still unknown. Neuronal nicotinic acetylcholine receptors (nAChRs) have been implicated in various neurological disorders, including schizophrenia. The previous reports have shown that CHRNA polymorphisms were involved in schizophrenia. This study is to explore the potential association between CHRNA5 (OMIM#118505) polymorphisms and schizophrenia susceptibility in a Chinese population.Methods and ResultsA case–control study was conducted with 384 schizophrenia patients and 687 controls. We genotyped eight single nucleotide polymorphisms (SNPs) distributed in CHRNA5. Regulome DB, HaploReg, and GTEx databases were used to calculate possible functional effects of the polymorphisms. The χ2 test, genetic model analysis, and haplotype analysis were involved in assessing genetic association between variants and schizophrenia risk. The results exhibited that rs17486278 (NC_000015.10:g.78575140A>C) was associated with a decreased risk of schizophrenia on the basis of the recessive model (adjusted OR = 0.37, 95%CI: 0.15–0.93) in females. Moreover, we found that the four variants rs588765, rs6495306, rs680244, rs692780 were extremely significant after being stratified by ≥45 years.ConclusionsOverall, our findings supported that the potential association existed between CHRNA5 polymorphisms and schizophrenia susceptibility in a Chinese population. But, large sample validation is needed to enhance the accuracy of our results.
Highlights
Schizophrenia, a serious mental illness, is characterized by the disharmony between mental activity and the realistic environment, the disharmony and disintegration of cognition, emotion, volition, and so forth
We found that the four variants rs588765, rs6495306, rs680244, rs692780 were significantly linked to the risk of schizophrenia after adjusted by ≥45 years (Table 4), but none of the sites exhibilited the association with schizophrenia risk with adjustment by
Note: Abbreviations: single nucleotide polymorphisms (SNPs): Single nucleotide polymorphism, odds ratio (OR): odd ratio, 95% CI: 95% confidence interval, HWE: Hardy–Weinberg equilibrium
Summary
Schizophrenia, a serious mental illness, is characterized by the disharmony between mental activity and the realistic environment, the disharmony and disintegration of cognition, emotion, volition, and so forth. It has shortened the lifespan and afflicts about 1% of the population all over the world (Leucht, Burkard, Henderson, Maj, & Sartorius, 2007). Few studies have been reported in the correlation between CHRNA5 polymorphisms and schizophrenia. The results reported may help in future studies of schizophrenia and contribute to easing the burden of this disease on individuals, families, and society
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