Impact of Benzimidazole Containing Scaffolds as Anticancer Agents through Diverse Modes of Action

Abstract

Background: Cancer has turned into a health issue that requires the most rapid attention. Because of the disease's global reach and the high number of deaths it causes, research and development of novel anticancer treatments that are both effective and have fewer adverse effects are crucial. According to a 2015 survey by the World Health Organization (WHO), cancer kills 8.8 million people each year, accounting for 60% of all fatalities. Effective anticancer medicines are currently being developed and in this concern, Benzimidazole-based scaffolds have played an important role. Objective: Because of its wide variety of biological properties and the widespread usage of benzimidazole as a potent anticancer agent, this study emphasizes the importance of this moiety as an anticancer agent. Results: The benzimidazole ring structure has a wide range of pharmacological activity in a number of drugs used to treat diseases such as hypertension, malaria, cancer, microbial diseases, inflammatory disorders, and more. Furthermore, this fused heterocycle benzimidazole core may interact with various anions and cations, as well as biomolecules, in the human body, resulting in a wide range of biological activities such as antineoplastic, antibacterial and antifungal, anti-inflammatory and analgesic, antihypertensive, antiviral, and antidepressant. Conclusion: The focus of this review is on recent advances in drug design and development, as well as benzimidazole derivatives and how they work on various sites of action.