IMPACT OF ADMISSION HYPERGLYCEMIA ON IN-HOSPITAL MORTALITY IN ACUTE AORTIC DISSECTION

Abstract

Objective: report suggests that admission hyperglycemia is associated with cardiovascular and cerebrovascular disease. However, there are limited studies on admission hyperglycaemia and in-hospital mortality in patients with acute aortic dissection (AAD) hypertension. Therefore, our study aimed to investigate these associations. Design and method: In this survey, we obtained data from an electronic database for analysis from January 1, 2010 to January 1, 2023, 1239. Patients were divided into two groups based on their blood glucose level (BGA) at the time of admission. The outcome was all-cause mortality during hospitalization. Multivariate regression analysis was performed to explore the relationship between hyperglycemia and inpatient mortality. Results: The study analyzed 1239 patients, of whom 77.1% were male, with a mean age of 53.0 years and a mean BGA of 6.1 mmol/L. The logistic regression analysis revealed that the in-hospital mortality for individuals with hyperglycemia was 2.53 times greater compared to those with the normoglycemia group (95% CI:1.68-3.80, P < 0.001), which remained statistically significant even after adjusting. However, significant interactions were not found in subgroup analyses. The sensitivity analysis did not alter the association between the two variables. Furthermore, it was observed that patients who were using insulin experienced a decrease in in-hospital mortality. Conclusions: Admission hyperglycemia has been found to have a positive correlation with an elevated risk of hospital mortality in hypertensive patients with AAD. It has been observed that using insulin to manage admission hyperglycemia can help reduce the risk of in-hospital mortality.