Abstract
BackgroundKidney transplantation is the treatment of choice in patient with end stage chronic kidney disease, offering the best long term survival and greater Quality of Life in this group of patients. Graft volume was correlated with improved renal function in living donor transplantations. The primary aim of this study was to correlate renal volume adjusted to body surface area with renal function one year (estimated glomerular filtration rate; eGFR) after kidney transplantation.MethodsThis single-center, prospective cohort study included 256 patients who underwent kidney transplantation from January 2011 through December 2015 at Hospital das Clínicas de Botucatu–UNESP. We evaluated three kidney measurements during the bench surgery; the final graft volume was calculated using the ellipsoid formula and adjusted to body surface area.ResultsIn the living donors there was positive correlation between adjusted graft volume and eGFR (r = 0.311, p = 0.008). Multivariate analysis revealed that low rejection rate and increased adjusted graft volume were independent factors correlated with eGFR. In deceased donors, there was no correlation between adjusted kidney volume and eGFR (r = 0.08, p = 0.279) in univariate analysis, but a multivariate analysis indicated that lower kidney donor profile index (KDPI), absence of rejection and high adjusted kidney volume were independent factors for better eGFR.ConclusionAdjusted kidney volume was positively correlated with a satisfactory eGFR at one year after living donor and deceased donor transplantations.
Highlights
End-stage renal disease is an increasingly prevalent public health problem [1,2]
Multivariate analysis revealed that low rejection rate and increased adjusted graft volume were independent factors correlated with eGFR
There was no correlation between adjusted kidney volume and eGFR (r = 0.08, p = 0.279) in univariate analysis, but a multivariate analysis indicated that lower kidney donor profile index (KDPI), absence of rejection and high adjusted kidney volume were independent factors for better eGFR
Summary
End-stage renal disease is an increasingly prevalent public health problem [1,2]. Currently, kidney transplantation is the best therapeutic indication for patients with end-stage renal disease; transplantation is associated with better quality of life and survival compared with dialysis [3]. improvements in immunosuppressive regimes have resulted in significant improvements in early renal function [4], long-term graft survival remains suboptimal. Kidney transplantation is the best therapeutic indication for patients with end-stage renal disease; transplantation is associated with better quality of life and survival compared with dialysis [3]. Previous studies have shown that a decrease in kidney mass may lead to hyperfiltration, causing albuminuria and glomerulosclerosis. These results suggest that the number of nephrons or “nephron dose” of the graft may be a contributing factor to graft function [7,8,9]. Kidney transplantation is the treatment of choice in patient with end stage chronic kidney disease, offering the best long term survival and greater Quality of Life in this group of patients. The primary aim of this study was to correlate renal volume adjusted to body surface area with renal function one year (estimated glomerular filtration rate; eGFR) after kidney transplantation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
