Abstract
Purpose: In osteoarthritis (OA) inflammation is considered a crucial factor for cartilage destruction and disease progression. Metalloproteinases, matrix metalloproteinases (MMPs) and disintegrins and metalloproteinases with thrombospondin motifs (ADAMTS), play a key role in the inflammation process in OA through their chondrodestructive potential. Further understanding of OA inflammation mechanisms, especially considering MMPs and ADAMTS, holds the opportunity for future treatment options. 45S5-bioactive glass (BG) has traditionally been used as a bone substitute material, but its bioactive characteristics have sparked a wide discussion for more widespread applications.
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