Abstract
Anti-PD1/PDL1 checkpoint therapy has been unsuccessful in myeloma patients. Adenosine is a new therapeutic target for cancer therapy. Two ectoenzymes, CD39 and CD73, catalyse adenosine from extracellular ATP. CD39 converts ATP to AMP and CD73 AMP to adenosine. When investigating the role of adenosine in the immune response patients, we found increased concentration of adenosine in bone marrow plasma from myeloma patients compared with healthy controls. CD39 was expressed on myeloma cells and immune cells whereas CD73 was found on leukocytes and stromal cells in the bone marrow.
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