Immunosuppression Therapy Posttransplantation Can Be Associated With a Different Clinical Phenotype for Diabetic Charcot Foot Neuroarthropathy

Abstract

Listen

Translate article

Proinflammatory changes in the immune phenotype of circulating blood monocytes in acute Charcot in diabetes have recently been described (1), but the effects of immunosuppression have not been investigated. This report describes a modified clinical phenotype for Charcot in three subjects on immunosupression therapy for previous transplantation—two live-related renal and one simultaneous pancreas kidney transplant. Charcot presented without typical features such that the early acute phase was difficult to define clinically. In the two in whom immobilization was not initially undertaken, deformity developed. All had previous proliferative retinopathy, neuropathy, and nephropathy resulting in end-stage renal failure. A 42-year-old woman with type 1 diabetes, duration 34 years, presented with 3 …