Abstract
Immunosuppression by hemorrhagic fever-causing viruses.
Highlights
The outcomes of human virus infections are tightly linked to cellular immune responses, which are initiated early in the course of the infection by the activation of the innate immune pathways
hemorrhagic fever (HF) viral replication and disease progression that can lead to severe symptoms, such as vascular leakage, hemorrhages and multi-organ failure, usually originate with a strong inhibition of IFN-induction and/or -signaling by these viruses [4]
The HF-causing viruses utilize multiple of their proteins to inhibit IFN-induction and/or IFN-signaling pathways in order to increase the efficacy of immunosuppression
Summary
The outcomes of human virus infections are tightly linked to cellular immune responses, which are initiated early in the course of the infection by the activation of the innate immune pathways. HF viral replication and disease progression that can lead to severe symptoms, such as vascular leakage, hemorrhages and multi-organ failure, usually originate with a strong inhibition of IFN-induction and/or -signaling by these viruses [4].
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