Abstract
Research on experimental animals conducted for nearly 30 years clearly prove that the ethanol and water extracts of propolis provided parenterally have an immunostimulatory effect. In addition, it was revealed that in case of experimental animals immunized with specific antigens, the influence of propolis extracts and their components increased the agglutination titre, phagocytosis and antibody production compared to the antigens themselves. Contemporary research on immunostimulatory properties of propolis extracts clearly indicate the activation of macrophages and the increase of antimicroorganisms immunity, as well as stimulation of the antibody production under the influence of ethanol and water extracts from propolis and their components (immunoadjuvants).The most important immunostimulatory components of propolis include caffeic acid, dicaffeoylquinic acids and caffeic phenylethyl ester (CAPE). The research presented in this study creates the possibility of applying propolis extracts and their components in practice for the production of immune serum on an industrial scale.
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