Abstract
Six children with Prader-Willi syndrome were studied in order to assess their plasma immunoreactive insulin and growth hormone levels in responses to oral glucose, protein-glucose meal, and intravenous l-arginine. Their responses were almost identical to those observed in children with long-standing obesity: marked hyperinsulinemia, blunted growth hormone responses, normal plasma glucose levels, and high fasting levels of free fatty acids. The plasma decrements in free fatty acids during administration of the different stimuli were, in general, similar to those of normal or obese children. It is suggested that the described hormonal changes are related to the obesity of children with Prader-Willi syndrome and by no means represent a characteristic hormonal profile of the syndrome, per se.
Published Version
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