Abstract
The present study demonstrates the alterations in the frequencies of helper, cytotoxic and suppressor T cells in blood of P. berghei infected and TPA immunized rodent host towards the induction of protective immune response. Statistically significant (p<0.005) number of CD4+ T cells was recorded on D9 [Post Challenge (PC)] meanwhile CD4+ Treg cells were found to be declined in immunized mice as compared to infected. This increase in frequencies of T helper cells points towards the stimulation of strong Th2 immune response in immunized mice. Statistically significant (p<0.005) decline was observed in the frequencies of CD8+ T cells on D9 (PC) in immunized mice. In infected controls cytotoxic T cells were also found to be increased after 24h post infection. Due to strong Th2 immune response, evident from lower frequencies of CD4+ Treg cells in immunized mice, complete protection was obtained. T reg population was found to be higher in infected controls and all control mice died.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of parasitic diseases : official organ of the Indian Society for Parasitology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
