Immunomodulatory therapy for bacterial infections in pregnant sows

Abstract

The paper presents data reflecting the titers of agglutinins to specific antigens in the blood of pregnant sows and the dynamics of T and B lymphocytes, with specific immunocorrection of general intestinal diseases with the OKZ vaccine containing the antigens of colibacillosis, salmonellosis, Klebsiellosis and Proteus infection, and PPS containing Sal.cholerae suis , Sal.typhimurium, Pasteurella multocida (serovars A, B, D) and streptococci (serogroups C and R) in combination with the immunomodulator metallosuccinate. It is known that the most common pathogens are opportunistic bacteria of the Enterobacteriaceae family: Escherichia coli, Proteus vulgaris, Klebsiella pneumonia, Morganella morgani, which are widely represented in the environment, and are also resident representatives of the normal microflora of animals. In this regard, the specific prevention of bacterial infections with the simultaneous stimulation of nonspecific immunity in pregnant sows is of scientific and practical importance. Specific prophylaxis of sows, in combination with metallosuccinate, increases agglutinin titers, respectively, to pasteurellosis antigen within 19.8% - 24.7%, salmonella antigens (S. cholerae suis 2.2 times, S. typhimurium 2.9 times) and by 77.9% after the second injection, to the Escherichiosis antigen by 9.2% -67.3% and to the streptococcal antigen by 2.8 times compared with the animals of the control group. An increase in agglutinin titers was found without the use of specific drugs, which characterizes metallosuccinate as a drug with antigenicity. The use of metallosuccinate in sows using specific biological products made it possible to activate the synthesis of B-lymphocytes within 47.7% after the first injection, by 50.7% 10 days after the second injection and by 42.6% 20 days after the second injection. Thus, in the studies carried out, a strategy and basic principles of simultaneous immune and metabolic correction of the body of pregnant sows have been proposed.