Immunomodulatory potential of bioactive compounds of betel leaf extract targeting COVID-19 immunological human host proteins: An in silico study

Hebber Tri Andira,Fatimawali Fatimawali,Kepel Billy Johnson,Tallei Trina Ekawati,Kalalo Marko Jeremia,Simanjuntak Siboantua Broolin

doi:10.7324/japs.2021.120208

Abstract

Bioanalytical HPLC method of Piper betle L. for quantifying phenolic compound, water-soluble vitamin, and essential oil in five different solvent extractsRayudika Aprilia Patindra Purba, Pramote Paengkoum

Highlights

Immunomodulatory agents derived from natural materials have emerged as promising candidates for treating COVID-19, which is caused by a highly pathogenic novel virus known as severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) (Tallei et al, 2021a)
This study aimed to identify novel immunomodulatory compounds derived from betel leaf for the treatment of COVID-19 symptoms, proinflammatory cytokines
According to Feuillet et al (2021), effective treatments for COVID-19 patients should include a combination of antivirals and immunomodulators

Summary

Introduction

Immunomodulatory agents derived from natural materials have emerged as promising candidates for treating COVID-19, which is caused by a highly pathogenic novel virus known as severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) (Tallei et al, 2021a). Plants contain active compounds that have been scientifically and clinically proven to be used in the treatment of a variety of diseases, both infectious and metabolic (Eddouks et al, 2021; Graf et al, 2010; Kwofie et al, 2021; Silva and Júnior, 2010; Wahab et al, 2021) They are sources of novel drug compounds for antiviral (Khairan et al, 2021; Rakib et al, 2020; Singh et al, 2020; Tallei et al, 2020), as well as immunomodulatory agents (Chakraborty et al, 2021; Jantan et al, 2015; Wen et al, 2012)

Objectives

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Results

Conclusion