Abstract
Simple SummaryPhosphorus and calcium are essential nutrients for body functions including the immune system and are generally supplemented to poultry diets. Phosphorus is also present in plant feedstuffs, bound as phytate, which can be used by enzymatic hydrolyzation in the chicken. A reduction of dietary mineral phosphorus might consequently be conceivable, without negatively influencing the immune system. The high concentration of calcium in diets for laying hens that is needed for eggshell formation may inhibit phytate degrading enzymes, and thus, decrease phosphorus availability for the hen. Both phytate degradation and several immune parameters are known to be strain-specific, making an interaction of the genetic background and the dietary phosphorus and calcium supply with the immune system likely. The aim of the study was to evaluate the impact of reduced concentrations of dietary phosphorus and calcium on the peripheral and gut-associated immune system in two laying hen strains. Reduced mineral phosphorus enhanced, while reduced calcium reduced several immune parameters. The two strains showed differences in many immune parameters, but only the impact of dietary phosphorus was influenced by the genetic background. These results suggest that dietary phosphorus and calcium supply may strain-specifically influence immune defense and protection against infection in chicken.Insufficient nutrient supply can impair the immune system, which is important for animal health and welfare. Since chicken can partly hydrolyze phytate, which is the primary phosphorus storage in plant seeds, a reduction of mineral phosphorus in the diets could be an option for more sustainable egg production. Laying hens require high concentrations of calcium that might inhibit the function of endogenous enzymes for phytate hydrolyzation. The objective of this study was to characterize the impact of standard and reduced dietary phosphorus and calcium concentrations on the number and functionality of immune cells in the peripheral and gut-associated immune system in a white and brown laying hen strain. Reduced mineral phosphorus enhanced several immune parameters such as B cells in blood and IgA concentrations in bile in both strains, and peripheral monocytes and γδ T cells in cecal tonsils in brown hens. Reduced calcium levels resulted in lower numbers of T cells in blood and cecal tonsils in both strains, suggesting negative effects on adaptive immunity. Differences between the two strains were found in almost all immune parameters. Results suggest a potentially beneficial effect of reduced dietary mineral phosphorus on the immune system that is dependent on the genetic background.
Highlights
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Dietary P affected monocytes dependent on strain (p = 0.006 for strain × P) to the effect that numbers in LB hens, but not in LSL hens, were higher when fed the P− diet
The present study showed that reductions in dietary P and Ca are associated with immunomodulatory effects on the peripheral and gut-associated immune system in laying hens
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The high concentration of calcium in diets for laying hens that is needed for eggshell formation may inhibit phytate degrading enzymes, and decrease phosphorus availability for the hen Both phytate degradation and several immune parameters are known to be strain-specific, making an interaction of the genetic background and the dietary phosphorus and calcium supply with the immune system likely. The objective of this study was to characterize the impact of standard and reduced dietary phosphorus and calcium concentrations on the number and functionality of immune cells in the peripheral and gut-associated immune system in a white and brown laying hen strain. Reduced mineral phosphorus enhanced several immune parameters such as B cells in blood and IgA concentrations in bile in both strains, and peripheral monocytes and γδ T cells in cecal tonsils in brown hens. Results suggest a potentially beneficial effect of reduced dietary mineral phosphorus on the immune system that is dependent on the genetic background
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