Abstract
Aims: To determine the immunomodulatory effect of aqueous extracts of Auricularia sp and Pleurotus sp mushrooms using an immunosuppression animal model. Study Design: Pre-clinical experimental study.
Highlights
Results show that aqueous extracts of Auricularia sp & Pleurotus sp mushrooms significantly (p
The rise in the total WBC count lowered by cyclophosphamide in Wistar rats was observed at mg/kg and 600mg of Auricularia sp, and 400mg/kg and 800mg/kg for Pleurotus sp extract
The Wistar rats treated with both mushroom species aqueous extracts had their white cell counts restored to almost near initial levels recorded on day 0 which were significantly greater than those observed in the control group
Summary
No mortality of Wistar rats was observed over the 28-day experimental period. Cyclophosphamide though caused statistically significant (p
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