Abstract
Immunomodulators are substances that stimulate, restore, suppress, or help to produce (adjuvant) or increase the desired immune response. Portulaca quadrifida is a traditional plant in the Ayurvedic system of medicine which has been reported to show a variety of therapeutic activities. This study was performed to investigate the immunomodulatory activity of P. quadrifida. Ethanolic extract of whole plant was administered orally at doses of 200 mg kg-1 and 400 mg kg-1 and septilin was used as reference standard. Septilin from Himalaya herbals is an ayurvedic polyherbal formulation. Septilin contains extracts and powders of Balsamodendron mukul and Shankh bhasma, and extracts of Maharasnadi quath, Tinospora cordifolia, Rubia cordifolia, Emblica officinalis, Moringa pterygosperma and Glycyrrhiza glabra. Septilin has been reported to possess immunomodulatory and antibacterial activity and it has been used in treatment of acute and chronic infections. The activity was determined by measuring delayed-type hypersensitivity, antibody titre, neutrophil adhesion and haematological parameters in sensitized rats. The study showed that there was significant increase in the total white blood cell count, antibody titre strength and neutrophil adhesion. The results clearly indicate that P. quadrifida shows potential immunostimulant activity at doses of 200 mg kg-1 and 400 mg kg-1.
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