ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC AND ANTIOXIDANT EFFECT OF HEDYOTIS LESCHENAULTIANA DC ON ALLOXAN INDUCED DIABETIC RATS

Abstract

The aim of this study was to investigate the effect of ethanol extract of whole plant of Hedyotis leschenaultiana (EEHL) as antihyperglycemic, antihyperlipidemic and antioxidant effect in alloxan induced diabetic rats. Diabetes was induced in wistar albino rats by administration of alloxan monohydrate (150mg/kg). The EEHL at a dose of 150 and 300mg/kg of body weight was administrated at single dose per day to diabetes induced rats for a period of 30 days. The effect of EEHL on blood glucose, insulin, urea, creatinine, HbA1C, serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP)], serum lipid profile, [total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C)] and lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and reduced glutathione (GSH) were measured in the diabetic rats. The EEHL elicited significant reduction of blood glucose (p<0.01), lipid parameters except HDL-C, serum enzymes and LPO and significantly reduced insulin (p<0.01), HDL-C, SOD, CAT, GPx and GSH at the dose of 300mg/kg was compared with the standard drug glibenclamide. From the above results, it is concluded that ethanol extract (300mg) of Hedyotis leschenaultiana whole plant possesses significant antihyperglycemic, antihyperlipidemic and antioxidant effect in alloxan induced diabetic rats.