Abstract
Article history: Received on: 08/09/2012 Revised on: 19/09/2012 Accepted on: 24/09/2012 Available online: The ethanol extract of Polygala rosmarinifolia whole plant (Family: Polygalaceae) was investigated for its antihyperglycemic and antihyperlipidaemic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of alloxan monohydrate (150mg/kg, i.p). The ethanol extracts of Polygala rosmarinifolia at a dose of 100 and 200mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of Polygala rosmarinifolia whole plant extract on blood glucose, serum insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglycerides (TG), low density lipoprotein – cholesterol (LDL-C), very low density lipoprotein–cholester (VLDL-C), high density lipoprotein – cholesterol (HDL-C) and phospholipid (PL)] serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminases (SGPT), serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)], were measured in the diabetic rats. The ethanol extract of Polygala rosmarinifolia whole plant elicited significant reductions of blood glucose (P<0.05), lipid parameters except HDL-C, serum enzymes and significantly increased HDL-C. The extracts also caused significant increase in serum insulin (P<0.05) in the diabetic rats. From the above results, it is concluded that ethanol extract of Polygala rosmarinifolia possesses significant antihyperglycemic and antihyperlipidaemic effects in alloxan induced diabetic rats.
Highlights
Diabetes mellitus (DM), a leading non communicable disease with multiple aetiologies, affects more than 100 million people Worldwide and is consider as one of the leading causes of death in the world (Zimmet, 1999)
The effect of ethanol extract of Polygala rosmarinifolia whole plant extract on blood glucose, serum insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglycerides (TG), low density lipoprotein – cholesterol (LDL-C), very low density lipoprotein–cholester (VLDL-C), high density lipoprotein – cholesterol (HDL-C) and phospholipid (PL)] serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminases (SGPT), serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)], were measured in the diabetic rats
It is concluded that ethanol extract of Polygala rosmarinifolia possesses significant antihyperglycemic and antihyperlipidaemic effects in alloxan induced diabetic rats
Summary
Diabetes mellitus (DM), a leading non communicable disease with multiple aetiologies, affects more than 100 million people Worldwide and is consider as one of the leading causes of death in the world (Zimmet, 1999). Diabetes mellitus is a multifactorial disease which is characterized by hyperglycemia, lipoprotein abnormalities, raised basal metabolic rats, defects in reactive oxygen species scavenging enzymes and high oxidative stress induced damage to pancreatic beta cells (Ugochukwa and Babady, 2003; Scoppoia et al, 2001; Owu et al, 2006; Kesavalu et al, 2000). This study was undertaken to evaluate the effects an ethanol extract of whole plant of Polygala rosmarinifolia on antihyperglycemic and anti hyperlipidamic activity in alloxan induced diabetic rats
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