Abstract
Immunization of animals with adultworm-and egg-antigen and passive immunization with antiserum were performed. With these animals, precipitin tests, change of serum protein and protection against reinfection were studied.I. protection against infection of S. japonicum was obtained in mice injected with adultworms-antigen but no protection was observed in mice immunized with eggs-antigen or immunized passively with antiserum.II. 2 antigens, prepared from adult-worms and eggs, gave positive results in precipitin test using immune sera of rabbits, immunized with adultworms-, eggs-antigen or immunized passively with antiserum.The highest precipitin titers of rabbits sera immunized with adultworm were 3, 200 X against adult test-antigen and 100 X against egg test-antigen. Sera from rabbits immunized with egg-antigen showed the highest precipitin titers of 800 X against adult test-antigen and 6, 400 X against egg test-antigen. Rabbits sera, immunized passively with antiserum of goats, gave positive reaction at 6, 400 fold dilution to adult or egg test-antigen.III. The change of serum protein in mice injected with suspension of adult-worms and eggs and antiserum from immunized goats was investigated by paper-electrophoresis. The serum protein of mice injected with suspension of adults showed remarkable increase of total protein slight increase in α-, β-globulin, increase in γ-globulin and remarkable decrease in A/G ratio. The serum protein of mice injected with suspension of eggs showed remarkable increase of total protein, slight increase in β-, γ-globulin and decrease in A/G ratio. Increase of total protein, slight increase in albumin and γ-globulin were observed in mice immunized passively with antiserum.
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