Abstract
SummaryImmunization with tetanus toxoid as humoral antibody formation and skin tests with DNCB, PPD and macrophage response as delayed cellular immune response have been performed in twenty patients with systemic lupus erythematosus (SLE) as well as in twenty controls matched for age and sex.No difference was found between the SLE group and the control group with respect to the frequency and intensity of positive reaction to tetanus toxoid while significant hyporeactivity to DNCB, PPD and macrophage response was found in SLE. This cutaneous hyporeactivity could not be correlated with presence of clinical activity, titer of antinuclear factors in serum and dosage of prednisolone.
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