Abstract
Precipitating antibodies against soluble antigens isolated from the filariae of O. volvulus were detected in 64% of sera tested from onchocerciasis patients, by the method of Ouchterlony. The presence of this type of antibody was not highly correlated with the presence or absence of ocular lesions. Skin-sensitizing antibody was demonstrated by passive transfer to a responsive normal individual in 15 of 19 sera so tested. Direct skin tests with microfilarial antigen were positive in 86% of a group of onchocerciasis patients and 13% of a control group, suggesting that further investigation of this type of test as an aid in diagnosis is warranted.
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