Abstract
Parvovirus infection in pregnant women caused the development of immunopathological reactions.129 infected pregnant women and 16 women with physiological pregnancy in the 1st, 2nd and 3rd trimesters were examined. The functional state of neutrophils (Nph) and monocytes (Mc) of peripheral blood was investigated, parameters of cellular and humoral immunity and cytokine profile of serum of pregnant women were studied. In infected pregnant women in different periods of gestation as compared with pregnant women of control groups there were observed 1) an increase of index of phagocytosis Nph and Mc against the background of reducе of their absorption capacity and increasing NBT-activity with a decrease of reserve capacities of phagocytes; 2) an activation of the cellular immunity with an increase of helper mechanisms of the immune response; 3) a reliable increase of IgM level in serum in different periods of pregnancy; 4) a reliable increase of the content of IFN-γ, FNP-α, IL-2, IL-8 inserum against the background of a slight decrease in the level of anti-inflammatory IL-10. The largest deviations from the control indicators were recorded in the 1st trimester of pregnancy.
Highlights
Immunological features of parvovirus infection in different pregnancy periods
Lakatoch P.W. Parvovirus infection in pregnant women caused the development of immunopathological reactions.129 infected pregnant women
The largest deviations from the control indicators were recorded in the 1st trimester of pregnancy
Summary
Предславинська, 9, Київ, 03150, Україна National Medical University named A.A. Bogomolets Department of obstetrics and gynecology N 1 Predslavinskaya str., 9, Kyiv, 03150, Ukraine. Было обследовано 129 инфицированных беременных и 16 женщин с физиологической беременностью в I, II и III триместрах. Изучали функциональное состояние нейтрофилов (Нф) и моноцитов (Мц) периферической крови, показатели клеточного и гуморального звена иммунитета и цитокиновый профиль сыворотки крови беременных женщин. У инфицированных беременных в различные сроки гестации по сравнению с беременными групп контроля наблюдалось: 1) повышение показателя фагоцитоза Нф и Мц на фоне снижения их поглотительной способности и увеличение НСТ-активности с уменьшением резервных возможностей фагоцитов; 2) активация клеточного звена иммунитета с ростом хелперных механизмов иммунного ответа; 3) достоверное повышение уровня сывороточного IgМ в І, ІІ и ІІІ триместрах; 4) достоверное повышение содержания ИФН-γ, ФНО-α, ИЛ-2, ИЛ-8 в сыворотке крови на фоне незначительного снижения уровня ИЛ-10. Наибольшие отклонения от контрольных показателей зафиксированы в I триместре беременности
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
