Abstract
Hydatidosis, a problem of worldwide importance is caused by larval (metacestode) stages of cestodes belonging to the genus Echinococcus. Non-classical human leukocyte antigen (HLA-G) plays an remarkable role in liver disease. This review will discuss sHLA-G and some immunological parameters in the study of Iraq patients with sterile and fertile hydated cyst. A study the immunological parameters include effect of Human Leukocyte Antigen-G which are investigated by ELISA, showed significant differentiation (P<0.05) at the serum level concentration in patients after surgery compared with the level of concentration before surgery and higher than in the control group with non-significant differences in the immune response between two types of fertile and sterile cyst. So, results of KIR2DL4 and ILT4 immunological receptor, which were investigated in patients’ blood using the flow cytometry, showed significant increase in concentration from these receptors for patients who suffer fertile and sterile hydatid cysts compared to the control group. Therefore changed immune responses in two type cysts with hydatidosis patients in presence sHLA-G expression.
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