Abstract
Antiserum was produced in rabbits to a partially purified LH fraction of human postmenopausal gonadotropin (HMG) and then absorbed with human serum and a potent FSH preparation from HMG. The absorbed antiserum appeared to be serologically specific to human urinary LH. This antiserum gave no demonstrable precipitin reaction with either a highly purified human pituitary LH preparation or serum gonadotropin, but did inhibit the OAAD activities of these 2 preparations. Neither precipitation nor neutralization occurred between the antiserum and HCG. The degree of immunologic cross-reactivity among various human LH preparations was examined by quantitative micro-complement fixation with the absorbed antiserum, and the following values of the immunologic index of dissimilarity were obtained: urinary LH 1.00, serum gonadotropin 3.1, pituitary LH 6.0 and HCG 1.0. Complement-fixing activities of nonpregnant urinary LH preparations were in good agreement with their LH potencies; however, this did not hold true for H...
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