Abstract
Stanniocalcin (STC) is a mammalian polypeptide hormone that appears to play a role in mineral metabolism through its regulatory effects on renal phosphate transport. In this report we have characterized tissue-derived STC in humans and found it to be a glycosylated, disulfide-linked dimer, with similar physical and chemical properties to baculovirus-expressed hormone. The hormone was localized to principal and α-intercalated cells in the distal half of the nephron. This is the first homologous demonstration of STC proteins and cells in human tissue.
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