Abstract
The Objective of the present study is to evaluate the expression levels of Bcl-2 and p53 proteins in squamous cell carcinoma and adenocarcinoma of the uterine cervix, and try to explain their role as prognostic markers for this cancer. The cohort comprised 90 cases of the cervix lesions. The samples were assessed by immunohistochemistry for the expression of Bcl-2 and p53 proteins. The results showed that the Bcl-2 expression was either absent, low or moderate respectively in 38.96%; 50.65% and 10.39% of SCC cases. However, it was absent or expressed in 76.92% and 23.08% of adenocarcinoma cases respectively. The p53 protein was absent or present respectively in 75.32% and 24.68% of SCC cases as demonstrated by immunohistochemistry. p53 was almost absent in adenocarcinoma samples where only 7.70% of cases were positive. There was no significant correlation between Bcl-2 and p53 expression (p=0.352). We conclude that p53 expression, detected by immunohistochemistry, does not appear to be a prognostic marker for cervical cancer. Nevertheless, Bcl-2 expression seems to provide more information for this disease. It may represent an important indicator for cervical cancer.
Highlights
Cervical cancer is the fourth most common cancer in women worldwide with an estimated one-half million of new cases in 2012
The purpose of this study is to evaluate the expression of p53 and Bcl-2 in Algerian cervical carcinoma samples in an attempt to explain their prognosis value using the immunohistochemistry detection
The Bcl-2 expression was always diffusely localized in the cytoplasm of the cells and was present in 47 of squamous cell carcinoma (61.04%)
Summary
Cervical cancer is the fourth most common cancer in women worldwide with an estimated one-half million of new cases in 2012. A large majority of the global burden occurs in developing countries. There were an estimated 266.000 deaths from this cancer worldwide in the same year. In Algeria, cervical cancer is the third most common cancer in women, with an incidence of 1,288 cases and 510 deaths estimated in 20121. The uterine cervix carcinoma includes both slowly and rapidly progressing tumours. The alteration in apoptosis disturbance, in immune surveillance, uncontrolled
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
