Abstract
Background: Squamous cell carcinoma (SCC) of the uterine cervix is a leading cause of morbidity and mortality among women. The alterations of Phosphatase and tensin homolog (PTEN), B-cell lymphoma 2 (Bcl2) and p53 expression seem to be significant in the development of various types of cancers. The altered expressions of PTEN, Bcl2 and p53 and their involvement in cancer of the uterine cervix are not well recognized. Aim: This study aimed at examining the expression patterns of PTEN, Bcl2 and p53 proteins and comparing them with the grade and stage of cervical cancer. Materials and Methods: Tissue blocks of SCC and ten cases of inflammatory lesions of the uterine cervix were examined immunohistochemically for the expression of PTEN, Bcl2 and p53 proteins. Results: Loss of PTEN expression was identified in 45.33% of cervical SCC and no expression was found in inflammatory lesions (p ≤ 0.05). PTEN expression was significantly associated with the clinical stage of SCC (61.36% and 45.16% in stages I–II and III–IV, respectively) (p < 0.05), but not with the degree of differentiation of the SCC. The expression of Bcl2 was significantly high (60%) in cancer cases than in control cases (p < 0.05). Bcl2 did not show any significant association with the histologic type and clinical stage of the SCC of the uterine cervix. The expression of p53 protein was significantly high (57.33%)) in cancer tissue, and no expression was noted in control cases (p < 0.05). Moreover, the expression pattern of p53 protein in cervical cancer tissue samples was not linked with the patient age, grade and stage of the cervical SCC (p > 0.05). Conclusion: The reduced expression of PETN and overexpressions of Bcl2 and p53 might play an indispensable role in carcinogenesis of cervical SCC. Moreover, a relationship was detected between PTEN expression and clinical stage of the cervical SCC.
Highlights
Cervical cancer is a cancer rising from the cervix and is a common malignancy of female gynecologic systems and contributes approximately 8% of altogether cancers [1]
Loss of Phosphatase and tensin homolog (PTEN) expression was identified as 45.33% (34/75) in cervix cancer and a high expression was noted in control cases (Figure 1b) with p < 0.05 (Table 1)
PTEN expression was significantly associated with the clinical stage of the squamous cell carcinoma (SCC) of the uterine cervix (61.36% and 45.16% in stages I–II and III–IV, respectively) (p < 0.05) (Table 1)
Summary
Cervical cancer is a cancer rising from the cervix and is a common malignancy of female gynecologic systems and contributes approximately 8% of altogether cancers [1]. Numerous factors are involved in the pathogenesis of cervical cancer, including human papillomavirus and alteration of cell signaling pathways. Previous findings have reported that the human papillomavirus infection is commonly detected in invasive cervical squamous cell carcinoma (SCC) [2]. Squamous cell carcinoma (SCC) of the uterine cervix is a leading cause of morbidity and mortality among women. The alterations of Phosphatase and tensin homolog (PTEN), B-cell lymphoma 2 (Bcl2) and p53 expression seem to be significant in the development of various types of cancers. The altered expressions of PTEN, Bcl and p53 and their involvement in cancer of the uterine cervix are not well recognized. Aim: This study aimed at examining the expression patterns of PTEN, Bcl and p53 proteins and comparing them with the grade and stage of cervical cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
