Abstract
Background: Breast cancer represents the most common and the first leading cause of cancer-associated deaths in Iraqi women. It is a heterogeneous disease with different subtypes; one of these subtypes is triple-negative (basal-like) breast cancer, which is characterized by a distinctive molecular profile, aggressive clinical behavior, and the absence of targeted therapies. Annexin A2 and Annexin A6 are part of the Annexin protein family; these proteins have a suggested role in the evolution and progression of many cancer types, including breast cancer. Evaluation of the immunohistochemical expression of Annexin A2 and Annexin A6 in triple-negative subtype) in a random sample group of Iraqi women patients and correlating the results with clinicopathological parameters, including tumor grade and stage.Methods: The current study was conducted in Baghdad /Iraq, in which forty paraffin-embedded blocks of breast tissue from women patients diagnosed with breast cancer were collected and selected to be triple-negative breast cancer. Immunohistochemical staining of Annexin A2 and Annexin A6 markers was performed for this sample with a correlation of the results with clinicopathological parameters, including tumor grade and stage.Results: The study demonstrates a significant association between Annexin A2 and Annexin A6 expression and a significant association between Annexin A2 expression and tumor grade and stage in triple-negative breast cancer in this group of Iraqi patients.Conclusions: This study displays the role of Annexin A2 and Annexin A6 in triple-negative breast cancer and suggests the role of Annexin A2 in the progression, metastasis, and prognosis of this special type of breast cancer by its association with advanced tumor grade and stage.Keywords: Annexin A2; Annexin A6; triple-negative; Breast cancer
Published Version
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