IMMUNOHISTOCHEMICAL EVALUATION OF ESTROGENRECEPTOR AND PROGESTERONE RECEPTOR IN UTERINESMOOTH MUSCLE CELLTUMORS

Abstract

Objective: To study the histo-morphological spectrum of uterine smooth cell tumors withimmunohistochemical expression of estrogen and progesterone receptor and to compare theirexpression with respect to that of surrounding myometrium. Materials & Methods: The study is conducted at a tertiary care hospital in northern India which included themyomectomy as well as hysterectomy specimens of the smooth muscle cell tumor. This study found th Results: at the majority of leiomyoma tumors express positivity for estrogen and progesterone receptors, with one-third showing moderate expression and the rest showing strong expression. The study concludes that the majority of Conclusion: uterine smooth muscle tumors are benign and hormone receptor expression, particularly ER, may play a crucial role in their development and progression, highlighting the need for further research to improve diagnostic and treatment approaches. Additionally, a decrease in hormone receptor expression was observed as tumors progressed from benign to malignant, but the conclusion is limited due to the small number of tumors demonstrating atypical characteristics