Abstract
Aim:Dental pulp stem cells, which are primarily derived from the pulp tissues of human teeth, have rarely been obtained from natal teeth. This study investigated the stem cell and differentiation markers of the dental pulp of natal teeth using immunohistochemistry.Materials & Methods:The pulp tissue from extracted natal teeth (n = 2) of a 20-day-old healthy male was examined for immunohistochemical expression of stem cell (Oct-4 and SOX 2) and differentiation markers (Nestin, CD 44, desmin, osteopontin and Ki- 67).Results:The pulp tissue of the natal teeth expressed immunopositivity for nestin, CD 44 and SOX2.Conclusion:Natal teeth, if preserved properly, could serve as sources of dental pulp stem cells that are an improvement on deciduous teeth.
Highlights
ObjectivesDental pulp stem cells, which are primarily derived from the pulp tissues of human teeth, have rarely been obtained from natal teeth
Our study provides evidence that natal teeth have shown very strong positive expression of CD44 (MSC), SOX2 (ESC) and Nestin (NSC) markers
Taken together, the results of this study support the use of natal teeth as a potential source of pluripotent stem cells for future cell-based therapies
Summary
Dental pulp stem cells, which are primarily derived from the pulp tissues of human teeth, have rarely been obtained from natal teeth. The purpose of this study was to characterize the stem cellness of the dental pulp obtained from natal teeth, which are in general considered waste teeth, using histological and immunohistochemical methods
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