Abstract
Objectives This study evaluated the immunoexpression of SOX2, FGF-10 and Wnt-1 in 20 cases of odontogenic keratocyst (OKC), 20 solid ameloblastoma (AM), 20 adenomatoid odontogenic tumor (AOT), 10 calcifying epithelial odontogenic tumor (CEOT) and 5 dental germs. Findings The analysis of SOX2 immunoexpression revealed positivity in most cases of the lesions. The immunostaining score for SOX2 revealed a statistically significant difference between the groups of lesions, with a higher frequency in OKC and CEOT (p Conclusions The expression pattern of SOX2, FGF-10 and Wnt-1 in dental germs and odontogenic lesions evaluated here confirms the participation of these proteins in the tooth development as well as in the development of benign epithelial odontogenic lesions.
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