Abstract
Timely provision of blood plays an important role in the management algorithm of patients. Interference by minor blood group (BG) antibodies has become a common entity among multi-transfused patients; other nonsignificant antibodies are too encountered rarely. We report one such interfering nonspecific antibody in a 55-year-old female patient posted for splenectomy at our institute. BG discrepancy (type one) with a pan-positive (4+) antibody screening panel was found in her testing results. Crossmatches were compatible at antihuman globulin phase and at room temperature, and autocontrol was negative. Detailed meticulous immunohematological workup helped us in concluding that the offending antibody was not directed against the ingredients of column matrix of gel cards or the enhancement media (low ionic strength solution); rather it was directed against the chemical constituents in the suspension medium of commercial cell panel. Bearing the presence of nonspecific “nuisance” antibodies in mind becomes extremely important so that they can be detected and managed quickly.
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