Abstract
In their recent TIBS article [1], Feige and colleagues place a strong emphasis on the role of the first immunoglobulin (Ig) constant domain, CH1, in preventing transport of the Ig heavy chain (HC) to the cell surface when Ig light chains are absent. This emphasis is in agreement with their own work, showing that the isolated CH1 is intrinsically disordered, as well as with numerous other data (e.g. [2]), and textbook representations of HC associated with binding immunoglobulin protein (BiP) in the endoplasmic reticulum (ER) in the absence of light chains.
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