Abstract
BackgroundCommunity-acquired lower respiratory tract infections (CA-LRTIs) are the primary cause of hospitalization among children globally. A better understanding of the role of atypical pathogen infections in native conditions is essential to improve clinical management and preventive measures. The main objective of this study was to detect the presence of 7 respiratory viruses and 2 atypical pathogens among hospitalized infants and children with community-acquired lower respiratory tract infections in Luzhou via an IgM test.MethodsOverall, 6623 cases of local hospitalized children with 9 pathogen-IgM results from 1st July 2013 to 31st Dec 2016 were included; multidimensional analysis was performed.Results1) Out of 19,467 hospitalized children with lower respiratory tract infections, 6623 samples were collected, for a submission ratio of 33.96% (6623 /19467). Of the total 6623 serum samples tested, 5784 IgM stains were positive, for a ratio of 87.33% (5784 /6623). Mycoplasma pneumoniae (MP) was the dominant pathogen (2548 /6623, 38.47%), with influenza B (INFB) (1606 /6623, 24.25%), Legionella pneumophila serogroup 1 (LP1) (485 /6623, 7.32%) and parainfluenza 1, 2 and 3(PIVs) (416 /6623, 6.28%) ranking second, third and fourth, respectively.2) The distribution of various pathogen-IgM by age group was significantly different (χ2 = 455.039, P < 0.05).3) Some pathogens were found to be associated with a certain age of children and seasons statistically.ConclusionsThe dominant positive IgM in the area was MP, followed by INFB, either of which prefers to infect children between 2 years and 5 years in autumn. The presence of atypical pathogens should not be underestimated clinically as they were common infections in the respiratory tract of children in the hospital.
Highlights
Community-acquired lower respiratory tract infections (CA-LRTIs) are the primary cause of hospitalization among children globally
Recent estimates suggest that nearly 120 million new cases of community-acquired pneumonia (CAP) occur each year, with almost 1 million deaths among children aged < 5 years [2]
He et al [4] reported that S. aureus, E. coli, and K. pneumonia were the common bacterial isolates recovered from children with CA-LRTIs during 2011–2015 in Dongguan
Summary
Community-acquired lower respiratory tract infections (CA-LRTIs) are the primary cause of hospitalization among children globally. The main objective of this study was to detect the presence of 7 respiratory viruses and 2 atypical pathogens among hospitalized infants and children with communityacquired lower respiratory tract infections in Luzhou via an IgM test. In 2016, CAP killed an estimated 880 000 children, Bacterial pathogens remain a major cause of CALRTIs in children, leading to continuous morbidity and mortality, in developing areas. He et al [4] reported that S. aureus, E. coli, and K. pneumonia were the common bacterial isolates recovered from children with CA-LRTIs during 2011–2015 in Dongguan. It is reported that the new strain of influenza A
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
