Immunogenetic Aspects Helicobacter Pylori Associated Gastroduodenal Pathology In Children

Shodieva Musharraf Sadirovna

doi:10.37547/tajmspr/volume02issue08-08

Abstract

We investigated the associations between the host HLA-DQ variation and the prevalence of H ruli in the Indonesian population with an H. pylori-infected level of 11.2% in people living in the Bukhara region. It was noted that individuals carrying the DQB1 * 0401 genotypes are at significantly greater risk of developing H infection. .lori compared to individuals with the DQB1 0301 genotypes. The DQA1 or DQB1 haplotypes were not associated with H. pulori infection.

Highlights

Chronic pathology of the stomach and duodenum in children and adolescents occupies a significant place in the structure of the overall morbidity [N
Helicobacter pylori (H. pylori) infection is currently considered as the leading etiopathogenetic factor of peptic ulcer disease (PUD) and chronic gastritis (CG) in childhood [Nizhevich A.A. et al 2010]
The results of large-scale studies have shown that the share of peptic ulcer disease associated with infection with Helicobacter pylori accounts for 70-80% of cases of detection of duodenal ulcers and 50-60% of gastric ulcers [Suerbaum S., 2002]

Summary

INTRODUCTION

Chronic pathology of the stomach and duodenum in children and adolescents occupies a significant place in the structure of the overall morbidity [N. Helicobacter pylori (H. pylori) infection is currently considered as the leading etiopathogenetic factor of peptic ulcer disease (PUD) and chronic gastritis (CG) in childhood [Nizhevich A.A. et al 2010]. The results of large-scale studies have shown that the share of peptic ulcer disease associated with infection with Helicobacter pylori accounts for 70-80% of cases of detection of duodenal ulcers and 50-60% of gastric ulcers [Suerbaum S., 2002]. Researchers associate 100% of cases of detection of proximal gastric cancer in Japanese with Helicobacter pylori infection [Uedo N .. Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine synthesized mainly by macrophages and monocytes, which plays an important role in the initiation and enhancement of the immune-inflammatory response to infection with H. pylori [GarciaGonzalez M.A. et al, 2005]. To study polymorphic variants of cytokine genes and their receptors in children with Helicobacter pylori associated gastroduodenal pathology

MATERIAL AND METHODS

AND DISCUSSION

Findings

CONCLUSIONS