Abstract
This paper concerns a patient who had long standing rheumatoid arthritis for which she received prednisone and chlorambucil. Steroid induced diabetes mellitus and subsequent cryptococcal meningitis caused her death. Circulating cryptococcal antigen was demonstrated in the patient's cerebrospinal fluid and blood by the latex cryptococcal antigen test. A new rapid method utilizing immunofluorescence to identify cryptococcal antigen and antibody in body fluids was utilized. The indirect fluorescent antibody test for detection of Cryptococcus was positive, utilizing the patient's serum antibody and the patient's cryptococcal organisms as the antigen. This test is a more specific and more sensitive diagnostic test than current serologic tests.
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