Abstract
Objective To find an effective way of offspring immunization with influenza vaccines in presence of maternal antibody.Methods Either influenza inactivated or DNA vaccines were used to immunize mice with various immunization strategies.After immunization,mice were challenged with a lethal dose of homologous virus.The efficacy of immunization was evaluated by measuring the survival rates,lung virus titers and antibody titers of the mice.Results When the offspring were immunized with the same vaccines as those for their mothers,whether inactivated or DNA vaccines,the active immune responses in offspring were inhibited by the presence of maternal antibody.However,the interference could be overcome under the following situations:immunization of offspring with neuraminidase DNA vaccine and immunization of their mothers with inactivated vaccines,or immunization of offspring with different DNA vaccines(hemagglutinin DNA or neuraminidase DNA)from those for their mothers.Conclusion Immunization of BALB/c mice with influenza DNA vaccine can avoid the interference of maternal antibody.The results provide an experimental basis for study on overcoming the immunosuppression caused by maternal antibody in neonates. Key words: Influenza A virus; Immunity,maternally-acquired; Vaccines,DNA; Hemagghtinins,viral; Neuraminidase
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