Abstract
：Objective To evaluateclinical outcome in postoperative patients with advanced gastric cancer treated withconcurrent chemotherapy and dendritic cells (DCs) vaccine as well as alteration of immunefunction. Methods Sixty-four postoperative patients with advance gastric cancer weredivided into control group and DC vaccine group, In control group, 38 patients weretreated with LCH regimen consisted of 5-fluorouracil 0.75 g/d_(1-5) and oxaliplatin 0.2g/d_1. In DC vaccine group,blood sample was obtained from 26 patients who were followed byLCH regimen treatment next day.One week after the chemotherapy, patients were immunizedwith DC vaccine for 2 times at interval of one week. The second cycle was performed after28 days. The percentages of T lymphocytes and natural killer (NK) cells and cytokinelevels before and after treatment were compared between two groups. The therapeuticeffects (including no remote metastasis and enlarged lymph nodes in cavity and/or tumorreduced in volume) were also evaluated. Results The concentrations of T lymphocytes (CD3~+and CD4~+ ), NK cells, interleukin (IL)-2, IL-12 and interferon-γ in DC vaccine group were significantly increased after vaccinationcompared with those before vaccination (P＜0.05), and even higher thanthose in control group (P＜0.05). The effective rate washigher in DC vaccine group (80. 76%) than that in control group (68.42%) with significantdifference (P＜0. 05). The side effects of chemotherapy such as the decreasedperipheral white blood ceils and immune cells were less serious in DC vaccine groupcompared with control group (P＜ 0.05), while theuncomfortable incidence of gastrointestinal tract and peripheral neuritis showed nosignificant difference between two groups (P＞0.05). Conclusions Application of concurrent chemotherapyand DC vaccine in patients with advanced gastric cancer after surgical treatment mayachieve a short-term efficacy, meanwhile it can reduce the side effects induced bychemotherapy. Key words: Stomach neoplasms; Denedrtic cells; Vaccines
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