Abstract
Twenty-eight children who received three doses of the quadrivalent rotavirus vaccine with 4 × 10 5 plaque-forming units (p.f.u.) were followed during a year after vaccination. Serum samples were obtained and evaluated for rotavirus IgA and neutralizing antibodies against vaccine and human rotavirus strains. At the end of the study, up to 61% of the children showed an increase in circulating IgA antibody levels. Nearly all of the vaccinated children increased their neutralizing antibody titres against the vaccine strains, and 25–54% against human rotavirus serotypes. After comparing the vaccinees with a population of children naturally infected with serotype G1 in the same study area, we conclude that three doses of 4 × 10 5 p.f.u. of the quadrivalent vaccine should prepare the child against future severe rotavirus diarrhea.
Published Version
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