Abstract
Objective:To study intervention effect of shikonin on immune function of dendritic cells using a rat allergic rhinitis model.Method: Forty rats were divided into three groups include OVA group(n=15),OVA+ shikonin group(n=15), and control group(n=10).The rat allergic rhinitis model was estabilshed after OVA sensitization and local challenge. 100 μg/ml shikonin was spray inhalated after OVA challenge in OVA+ shikonin group. The expression of CD80,CD86,IL-10 and IL-12 was deteced by immunohistochemistry in three groups.Result: In OVA+ shikonin group, the CD80 value was 13.52± 3.53,CD86 value was 24.01±13.12;in OVA group, the CD80 value was 17.19± 4.42 and the CD86 value was 38.89±9.77.The IL-10 value was 6.69±1.12 and 3.61± 0.23 in OVA group and OVA+ shikonin group,respectively.The IL-12 value was 44.30± 9.70 and 28.80+8.20 in OVA group and OVA+ shikonin group,respectively.Conclusion:The shikonin has effect on immune modulation in rat model of allergic rhinitis.
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