Abstract
We read with interest the study published by Kastelein et al1 in a recent issue of Gastroenterology. The authors investigated the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and statins on the risk of neoplastic progression from Barrett's esophagus (BE). The use of NSAIDs and statins was associated with a 53% and 54% risk reduction, respectively (hazard ratio [HR], 0.47 [95% confidence interval (CI), 0.24–0.93] and HR, 0.46 [95% CI, 0.21–0.99]). Furthermore, the use of a combination of NSAIDs and statins was associated with an even stronger risk reduction (HR, 0.22; 95% CI, 0.06–0.85).
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