Abstract
AbstractThe immobilization of a broad‐spectrum antibiotic amikacin on macromolecules of dextran previously modified with epichlorohydrin is described. It is shown that the release of amikacin is observed only in the presence of dextranase, which is produced by bacteria. For the first time, biocomposite materials based on the Glisson capsule of the liver and the pericardium, containing a layer of grafted dextran acting as a carrier of amikacin and capable of releasing amikacin derivatives that have antibacterial activity in the case of infection, have been developed. It was found that the release rate of amikacin derivatives formed in the presence of dextranase is determined by diffusion and is inversely proportional to the squared thickness of the dextran‐containing layer on the surface of biocomposite materials. © 2020 Society of Chemical Industry
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