Abstract
Vocal fold vibration is vital in voice production and the correct pitch of speech. We have developed a high speed functional optical coherence tomography (OCT) system with a center wavelength of 1050 nm and an imaging speed of 100,000 A-lines per second. We imaged the vibration of an ex-vivo swine vocal fold. At an imaging speed of 100 frames per second, we demonstrated high quality vocal fold images during vibration. Functional information, such as vibration frequency and vibration amplitude, was obtained by analyzing the tissue surface during vibration. The axial direction velocity distribution in the cross-sectional images of the vibrating vocal folds was obtained with the Doppler OCT. The quantitative transverse direction velocity distribution in the cross-sectional images was obtained with the Doppler variance images.
Highlights
Optical coherence tomography (OCT) is a powerful interferometric technology used to obtain cross-sectional tissue images noninvasively with micrometer resolution, millimeter penetration depth, and a video-rate imaging speed [1]
We have developed a high speed functional optical coherence tomography (OCT) system with a center wavelength of 1050 nm and an imaging speed of 100,000 A-lines per second
At an imaging speed of 100 frames per second, we demonstrated high quality vocal fold images during vibration
Summary
Optical coherence tomography (OCT) is a powerful interferometric technology used to obtain cross-sectional tissue images noninvasively with micrometer resolution, millimeter penetration depth, and a video-rate imaging speed [1]. Vocal fold vibration has been widely imaged using laryngeal videostroboscopy and high speed video, as these methods provide clinically relevant important information on vocal fold behavior in health and pathology. There is a wide spectrum of diseases that can occur in the vocal folds, including benign polyps, premalignant and malignant lesions Differentiating these afflictions using only direct visualization can be difficult and a biopsy is often required. Our group has demonstrated in-vivo imaging of human vibrating vocal folds with a 1.3 μm, 20 kHz swept source OCT system and a hand-held probe [15]. Functional information, such as vibrating frequency, was obtained by analysis of the OCT structure images. With the help of the particle image analysis method, the authors obtained the velocity vector in the cross section images from the OCT structure images
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