Abstract
T cells are the drivers of adaptive immunity and detect antigens with unprecedented sensitivity and selectivity. To understand this process, studying the very first interaction of a T cell with an antigen presenting cell (APC) is key. In order to detect an antigen, a close physical contact with the APC needs to be established. This process heavily relies on the interaction of adhesion proteins. Furthermore, the T-cell surface is dominated by microvilli (MV), which are dynamic membrane protrusions involved in antigen search.
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