Abstract
BackgroundGlutamate (GLU) is one of the most important excitatory neurotransmitters in central nervous system (CNS). GLU is involved in many CNS diseases, which is well reported that it is closely related to the infectious diseases in CNS. Brain abscess is a common disease in CNS. GLU chemical exchange saturation transfer MRI (GLUCEST) is used to explore the changes of glutamate concentration in the brain abscess models. MethodsFirstly, a SD rat brain abscess model was established by using Staphylococcus aureus in the right frontal lobe of SD rats. Secondly, imaging of normal SD rats and brain abscess rats were obtained in Agilent 7.0T animal magnetic resonance scanner respectively. Finally, all data are processed on Matlab. ResultsGLUCEST clearly delineated brain abscess at Z spectra. The CEST map of the brain abscess rats showed that the glutamate CEST effect in the lesions was significantly higher than that in the normal SD rats (p < 0.05). ConclusionsGLUCEST may provide new insight into brain abscess and help to improve the differential diagnosis.
Published Version
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